Various fields have examined the activity of flirting, predominantly based on experimental and reported data; the interactional workings are therefore often overlooked. Based on emails and chats from two Danish online dating sites, this article investigates how users negotiate romantic connections through the flirting strategy of ‘imagined togetherness’, linguistically constructing imagery of a shared future. Using the notion of the chronotope, turn-by-turn analysis demonstrates how users, embedded in the activity of getting to know each other, tenuously communicate romantic interest by (...) alluding to future points at which they might be together. Central to the strategy is a sequential pattern of avoiding closure and thereby preserving the imagery’s implicitness. The article concludes by arguing that while imagined togetherness functions to probe interests and thus protects oneself from potential rejection, it also draws on fundamental dynamics of fantasy in nourishing the excitement of romantic possibility. (shrink)

Conceptual engineering is the enterprise of evaluating and improving our representational devices. But how should we conduct this enterprise? One increasingly popular answer to this question proposes that conceptual engineering should proceed in terms of the functions of our representational devices. In this paper, we argue that the best way of understanding this suggestion is in terms of normative functions, where normative functions of concepts are, roughly, things that they allow us to do that matter normatively (for example, things in (...) virtue of which we have normative reasons to have these concepts). Not only does this introduce a novel view about functions to the literature. This proposal also fits more naturally than the alternatives with conceptual engineering as a normative enterprise, and it allows functions to play all of the explanatory roles assigned to them in the conceptual engineering literature. Our discussion of the explanatory advantages of normative functions also advances the understanding of the ways in which concepts can be authoritative, what this means for conceptual engineering, and highlights the importance of political philosophy for thinking about conceptual engineering in practice. Furthermore, the paper explicates what kind of role considerations about function can and should actually play in conceptual engineering. (shrink)

: Competing accounts of change and motion are given by the seventh-century Buddhist logician Dharmakirti and the contemporary analytical philosopher Graham Priest. They agree on much, but disagree on the issue of the Law of Non-Contradiction. This paper takes Dharmakirti's side, appealing to current space-time theory, while making some qualifications.

One of Arthur Prior’s constructions of the relational calculus for times within tense logic plus propositional quantifiers is considered using Malcolm Rennie’s multimodal semantics and found wantin...

Intuitionist mathematics has claimed a philosophy deriving from Kant. This paper aims to draw attention to significant similarities with a much older source, Aristotle. At the same time, the connection should not be over-stretched, given two millennia between them.

The problem of why something exists rather than nothing is doubtless as old as human philosophising. Of comparable antiquity is the observation that one cannot hope to explain why something exists rather than nothing by appealing to the existence of something else, on pain of vicious circularity.In this paper, I distinguish between the question of why anything exists, and the question of why particulars exist. These two questions are equivalent only if the only things that exist are particulars. Certainly many (...) have held that universals as well as particulars exist. I take it here that there is a prima facie distinction between universals and particulars. It follows that the former question is prima facie more general than the latter. I will initially concentrate on the latter, taking a hint from some recent theorising about the physics of the Big Bang. (shrink)

"A serious and good philosophical work could be written consisting entirely of jokes." -- Ludwig Wittgenstein The good news is that this book offers an entertaining but enlightening compilation of Žižekisms. Unlike any other book by Slavoj Žižek, this compact arrangement of jokes culled from his writings provides an index to certain philosophical, political, and sexual themes that preoccupy him. Žižek's Jokes contains the set-ups and punch lines -- as well as the offenses and insults -- that Žižek is famous (...) for, all in less than 200 pages. So what's the bad news? There is no bad news. There's just the inimitable Slavoj Žižek, disguised as an impossibly erudite, politically incorrect uncle, beginning a sentence, "There is an old Jewish joke, loved by Derrida..." For Žižek, jokes are amusing stories that offer a shortcut to philosophical insight. He illustrates the logic of the Hegelian triad, for example, with three variations of the "Not tonight, dear, I have a headache" classic: first the wife claims a migraine; then the husband does; then the wife exclaims, "Darling, I have a terrible migraine, so let's have some sex to refresh me!" A punch line about a beer bottle provides a Lacanian lesson about one signifier. And a "truly obscene" version of the famous "aristocrats" joke has the family offering a short course in Hegelian thought rather than a display of unspeakables. _Žižek's Jokes_ contains every joke cited, paraphrased, or narrated in Žižek's work in English, including different versions of the same joke that make different points in different contexts. The larger point being that comedy is central to Žižek's seriousness. (shrink)

In an introduction to tbe tbeology and moral pbilosopby of tbe Danisb tbinker, K. E. Legstrup, tbe starting point ist taken in bis on pbenomenological basis developed pbilosopby of creation. Tbe vibrant discussion in Denmark in tbe fifties between K. E. Legstrup an N. H. See conceming a specific cbristian etbics is evaluated and it is sbown bow Legstcups etbical tbinking developed in two directions. On tbe one band be expands bis pbilosopby of creation into metapbysical reflections in order to (...) substantiate bis solution to tbe problern of tbe foundations of etbics. On tbe otber band be anticipates a development towards applied etbics. (shrink)

This collection of essays provides a reassessment of the question of sexual difference, taking into account important shifts in feminist thought, post-humanist theories, and queer studies. The contributors offer new and refreshing insights into the complex question of sexual difference from a post-feminist perspective, and how it is reformulated in various related areas of study, such as ontology, epistemology, metaphysics, biology, technology, and mass-media.

Meta-ethical expressivism was traditionally seen as the view that normative judgements are not beliefs. Recently, quasi-realists have argued, via a minimalist conception of “belief”, that expressivism is fully compatible with normative judgements being beliefs. This maneuver is successful, however, only if quasi-realists have really offered an expressivist-friendly account of belief that captures all platitudes characterizing belief. But, quasi-realists’ account has a crucial gap, namely how to account for the propositional contents of normative beliefs in an expressivist-friendly manner. In particular, quasi-realists (...) haven’t yet developed their preferred option, a “minimalist” or “deflationist” account of such contents. This paper aims to close that gap. I argue that expressivists who accepts conceptual role semantics and use an account of that-clauses in their use in belief-attributions based on Wilfrid Sellars’ work can give a deflationary account of the contents of beliefs that is compatible with normative judgements being beliefs, even if expressivism is true. (shrink)

Once symbolized by a burning armchair, experimental philosophy has in recent years shifted away from its original hostility to traditional methods. Starting with a brief historical review of the experimentalist challenge to traditional philosophical practice, this chapter looks at research undercutting that challenge, and at ways in which experimental work has evolved to complement and strengthen traditional approaches to philosophical questions.

Advances in artificial intelligence research allow us to build fairly sophisticated agents: robots and computer programs capable of acting and deciding on their own. These systems raise questions about who is responsible when something goes wrong—when such systems harm or kill humans. In a recent paper, Sven Nyholm has suggested that, because current AI will likely possess what we might call “supervised agency”, the theory of responsibility for individual agency is the wrong place to look for an answer to the (...) question of responsibility. Instead, or so argues Nyholm, because supervised agency is a form of collaborative agency—of acting together—the right place to look is the theory of collaborative responsibility—responsibility in cases of acting together. This paper concedes that current AI will possess supervised agency, but argues that it is nevertheless wrong to think of the relevant human-AI interactions as a form of collaborative agency and, hence, that responsibility in cases of collaborative agency is not the right place to look for the responsibility-grounding relation in human-AI interactions. It also suggests that the right place to look for this responsibility-grounding relation in human-AI interactions is the use of certain sorts of agents as instruments. (shrink)

Formal principles governing best practices in classification and definition have for too long been neglected in the construction of biomedical ontologies, in ways which have important negative consequences for data integration and ontology alignment. We argue that the use of such principles in ontology construction can serve as a valuable tool in error-detection and also in supporting reliable manual curation. We argue also that such principles are a prerequisite for the successful application of advanced data integration techniques such as ontology-based (...) multi-database querying, automated ontology alignment and ontology-based text-mining. These theses are illustrated by means of a case study of the Gene Ontology, a project of increasing importance within the field of biomedical data integration. (shrink)

Should artificial agents (such as robots) be granted moral status? This seems like an important question to resolve, given that we will encounter a growing number of increasingly sophisticated artificial agents in the not too distant future. However, many will think that before we can even start to tackle questions about the moral status of artificial agents, we first need to solve tricky issues in the philosophy of mind. After all, most orthodox views about moral status imply that only entities (...) with a mental life are eligible for moral status. But, whether an unfamiliar entity like an artificial agent has a mental life raises controversial questions in the philosophy of mind. Given this, one might hope that we can resolve questions about the moral status of robots via “minimalist” views that give sufficient conditions for granting moral status to an entity that we can know to be satisfied without knowing whether the entity in question has a mind. This paper argues that we should be pessimistic about the prospects of minimalist views avoiding controversial questions in the philosophy of mind, by arguing that minimalist sufficient conditions are only plausible if combined with assumptions in the philosophy of mind. (shrink)

It has recently been suggested that meta-normative expressivism is best seen as a meta-semantic, rather than a semantic view. One strong motivation for this is that expressivism becomes, thereby, compatible with truth-conditional semantics. While this approach is promising, however, many of its details are still unexplored. One issue that still needs to be explored in particular, is what accounts of propositional contents are open to meta-semantic expressivists. This paper makes progress on this issue by developing an expressivist-friendly deflationary account of (...) such contents. (shrink)

While the meta-ethical error theory has been of philosophical interest for some time now, only recently a debate has emerged about the question what is to be done if the error theory turns out to be true. This paper argues for a novel answer to this question, namely revolutionary expressivism: if the error theory is true, we should become expressivists. Additionally, the paper explores certain important but largely ignored methodological issues that arise for reforming definitions generally and with a vengeance (...) in the context of a radical error theory about all practical normative judgements, and suggests how these issues can be resolved. (shrink)

Our view is that the folk concept of knowing how is more complicated than many epistemologists assume. We present four studies that go some way towards supporting our view—that the folk concept of knowledge-how is a philosophical hybrid, comprising both intellectualist and anti-intellectualist features. One upshot is, if we are going to award a presumptive status to philosophical theories of know-how that best accord with the folk concept, it ought to go to those that combine intellectualist and anti-intellectualist elements.

This paper develops in certain directions the work of Meyer in [3], [4], [5] and [6]. In those works, Peano’s axioms for arithmetic were formulated with a logical base of the relevant logic R, and it was proved finitistically that the resulting arithmetic, called R♯, was absolutely consistent. It was pointed out that such a result escapes incau- tious formulations of Goedel’s second incompleteness theorem, and provides a basis for a revived Hilbert programme. The absolute consistency result used as a (...) model arithmetic modulo two. Modulo arithmetics are not or- dinarily thought of as an extension of Peano arithmetic, since some of the propositions of the latter, such as that zero is the successor of no number, fail in the former. Consequently a logical base which, unlike classical logic, tolerates contradictory theories was used for the model. The logical base for the model was the three-valued logic RM3, which has the advantage that while it is an extension of R, it is finite valued and so easier to handle. The resulting model-theoretic structure is interesting in its own right in that the set of sentences true therein consti- tutes a negation inconsistent but absolutely consistent arithmetic which is an extension of R♯. In fact, in the light of the result of [6], it is an extension of Peano arithmetic with a base of a classical logic, P♯. A generalisation of the structure is to modulo arithmetics with the same logical base RM3, but with varying moduli. We first study the properties of these arithmetics in this paper. The study is then generalised by vary- ing the logical base, to give the arithmetics RMni, of logical base RMn and modulus i. Not all of these exist, however, as arithmetical properties and logical properties interact, as we will show. The arithmetics RMni give rise, on intersection, to an inconsistent arithmetic RMω which is not of modulo i for any i. We also study its properties, and, among other results, we show by finitistic means that the more natural relevant arithmetics R♯ and R♯♯ are incomplete. In the rest of the paper we apply these techniques to several topics, particularly relevant quantum arithmetic in which we are able to show that the law of distribution remains unprovable. Aside from its intrinsic interest, we regard the present exercise as a demonstration that inconsistent theories and models are of mathematical worth and interest. (shrink)

Functions play an important role in neo-pragmatism. This paper advances neo-pragmatism’s prospects by investigating how functions are to be understood on this account. It argues that prominent ways of understanding functions do not suit neo-pragmatists’ meta-semantic commitments or their preferred methodology. It then presents an account that fits both, based on Laura and François Schroeter’s theory of rationalizing self-interpretation. On this account, a term’s function is what it allows us to do that makes our tradition with the term rational.

Quasi-realists argue that meta-ethical expressivism is fully compatible with the central assumptions underlying ordinary moral practice. In a recent paper, Andy Egan has developed a vexing challenge for this project, arguing that expressivism is incompatible with central assumptions about error in moral judgments. In response, Simon Blackburn has argued that Egan's challenge fails, because Egan reads the expressivist as giving an account of moral error, rather than an account of judgments about moral error. In this paper I argue that the (...) challenge can be reinstated, even if we focus only on the expressivist's account of judgments about moral error. (shrink)

Paraconsistent logic, logic in which inconsistent information does not deliver arbitrary conclusions, is one of the fastest growing areas of logic, with roots in profound philosophical issues, and applications in information processing and philosophy of science. This book contains selected papers presented at the First World Congress on Paraconsistency, held in Ghent in 1997. It contains papers on various aspects of the subject. As such, it should be of interest to all who want to learn what the subject is, and (...) where it is going. (shrink)

Quasi-realism prominently figures in the expressivist research program. However, many complain that it has become increasingly unclear what exactly quasi-realism involves. This paper offers clarification. It argues that we need to distinguish two distinctive views that might be and have been pursued under the label “quasi-realism”: conciliatory expressivism and quasi-realism properly so-called. Of these, only conciliatory expressivism is a genuinely meta-ethical project, while quasi-realism is a first-order normative view. This paper demonstrates the fruitfulness of these clarifications by using them to (...) address Terence Cuneo’s recent challenge that quasi-realist expressivists lack the resources to plausibly accommodate certain sorts of data points. (shrink)

Many of the recent advances in the history of science have come from local microstudies, but with the unintended by‐product of a typically “postmodern” fragmentation of knowledge. The question for us post‐postmodernists is how to write a broader “general” history of science—a history for all of us specialists—without losing the advantages of case study. One way, this essay suggests, is to structure case studies around the activities or issues that are common to knowledge production generally: for example, issues of common (...) practices, role and identity, credibility and trust, fairness in participation and reward, and translocal circulation. Such studies would be particular and local yet transcend the singularities of period, place, and discipline. They would facilitate productive contest over the general meaning of science in its diversely varied forms. (shrink)

One objection that has been raised for meta-ethical expressivism is that expressivists must give an account of the nature of the attitude which constitutes moral thinking, but that any expressivist account that attempts to do seems to fail. Call this objection the “moral attitude problem.” In this article I suggest a strategy for expressivists to escape this problem: I argue that the moral attitude problem is a problem that arises not only for expressivists but also for meta-ethical cognitivists, and that (...) expressivists can use the same resources used by cognitivists to escape this problem. (shrink)

A core commitment of meta-ethical expressivism is that ordinary descriptive judgements are representational states, while normative judgements are non-representational directive states. Traditionally, this commitment has been understood as a psychological thesis about the nature of normative judgements, as the view that normative judgements consist in certain sorts of conative propositional attitudes. This paper’s aim is to challenge this reading and to show that changing our view on how this commitment is to be understood opens up space for attractive forms of (...) expressivism. The paper argues this by example: by presenting one of the possible expressivist views that can be developed on this reading and by arguing that this view has distinctive advantages over forms of expressivism that endorse the traditional interpretation of expressivism. (shrink)

ABSTRACT After a productive start in the 1980s, laboratory history is now surprisingly neglected—not lab science, but the lab as social institution. To restart interest, I suggest that we see labs as period specific (early modern, modern, postmodern) and of a piece with each era's dominant social institutions and practices. In the modern era, for example, labs have become powerful and ubiquitous because their operating principles are those of the nation-state and its consumerist political economy. Their educational function is crucial: (...) labs have authority because they are an effective vehicle for educating en masse for life in modern states; they provide general entry to careers in scores of disciplines and a thousand occupations; and they embody prevailing ideals of a meritocracy of competence, transparency (through publication), and a universalistic logic of objectivity. An older microhistory of laboratory practices may thus be reborn as a systematic, macrosocial history of the lab. (shrink)

Moral responsibility seems to presuppose personal identity. However, there are problems with this view, raised by Derek Parfit’s arguments for the view that personal identity isn’t what matters for our practical concerns. While Parfit discusses moral responsibility only in passing, the problems that arise for the connection between moral responsibility and personal identity have recently been sharpened by David Shoemaker. This paper defends the claim that moral responsibility presupposes personal identity against these problems. It argues, first, that only reductionist views (...) about personal identity have problems with the connection between responsibility and identity, which suggests that personal identity is a non-reductionist concept. Second, it argues that while non-reductionism is problematic, there is a novel view—non-representationalism about personal identity, according to which we account for personal identity in terms of a distinctive non-representational function—that is equally well-positioned to rescue the connection as non-reductionism, without suffering from non-reductionism’s problems. (shrink)

One worry about metaethical expressivism is that it reduces to some form of subjectivism. This worry is enforced by subjectivists who argue that subjectivism can explain certain phenomena thought to support expressivism equally well. Recently, authors have started to suggest that subjectivism can take away what has often been seen as expressivism's biggest explanatory advantage, namely expressivism's ability to explain the possibility of moral disagreement. In this paper, I will give a response to an argument recently given by Frank Jackson (...) to this conclusion that will show that it is false that subjectivism could explain disagreement as well as expressivism. (shrink)

Empathy means understanding another person’s emotional or intentional state by vicariously sharing this state. As opposed to emotional contagion, empathy is characterized by the self–other distinction of subjective experience. Empathy develops in the second year, as soon as symbolic representation and mental imagery set in that enable children to represent the self, to recognize their mirror image, and to identify with another person. In experiments with 126 children, mirror recognition and readiness to empathize with a distressed playmate were investigated. Almost (...) all recognizers showed compassion and tried to help, whereas nonrecognizers were perplexed or remained indifferent. Several motivational consequences of empathy are discussed and its special quality is outlined in comparison with theory of mind and perspective taking. (shrink)

Despite the efforts of meta-ethical expressivists to rebut such worries, one objection raised over and over again against expressivism is that, if the theory is true, matters of morality must be mind-dependent in some objectionable way. This paper develops an argument which not only shows that this is and cannot be the case, but also – and perhaps more importantly – offers a diagnosis why philosophers are nevertheless so often led to think otherwise.

Despite the efforts of meta-ethical expressivists to rebut such worries, one objection raised over and over again against expressivism is that, if the theory is true, matters of morality must be mind-dependent in some objectionable way. This paper develops an argument which not only shows that this is and cannot be the case, but also – and perhaps more importantly – offers a diagnosis why philosophers are nevertheless so often led to think otherwise.

There was a time when meta-ethical expressivism seemed to be the only game in town for meta-ethical non-representationalists. In recent years, though, meta-ethical inferentialism has emerged as a promising non-representationalist alternative. So far, however, inferentialists lack something that would really allow them to draw level with expressivists. This is an explanation for the distinctive difference between normative and descriptive vocabulary when it comes to disagreement—something expressivists can explain in terms of the difference between representational and desire-like states and which constitutes (...) one of the primary motivations for expressivism. This paper develops a novel and distinctive account for this difference on behalf of inferentialists, based on the different functions of these two vocabularies. Not only does this account help inferentialists, it also shows how non-representionalist accounts can capture the relevant disagreement phenomena without appealing to the sorts of desire-like states expressivists tend to appeal to. (shrink)

What general conclusions can be drawn about the reception of zymase, its relation to the larger shift from a protoplasm to an enzyme theory of life, and its status as a social phenomenon?The most striking and to me unexpected pattern is the close correlation between attitude toward zymase and professional background. The disbelief of the fermentation technologists, Will, Delbrück, Wehmer, and even Stavenhagen, was as sharp and unanimous as the enthusiasm of the immunologists and enzymologists, Duclaux, Roux, Fernback, and Bertrand, (...) and of Pfeffer, the experimental plant physiologist. Other skeptics—Voit, Kupffer, and Fischer—were conservatives in traditional fields. In all these cases it seems clear that professional commitments and outlook profoundly influenced the reception of zymase.In some cases there is a correlation with a specific earlier statement favoring the protoplasm theory or predicting a fermentation enzyme. Reynolds Green is a striking case of both. In 1893 he stated his belief that life processes in higher plants and fungi were identical, both being mediated by protoplasm.109 Thus he claimed that digestion was not carried out by enzymes, as in higher animals, but by the whole protoplasm, and so too fermentation in yeast: “All the metabolic processes must be carried out in the unicellular organism in the same mass of protoplasm.”110 But Green also insisted that there was no essential difference between “organized” and “unorganized ferments”; enzymes were simply more highly differentiated and specialized forms of primitive protoplasm. He spoke of “the alcoholic ferment” (that is, enzyme), and of intracellular enzymes—very advanced beliefs for 1893. Thus it is understandable why Green saw no reason to doubt his first negative results with yeast juice, and rushed into print. But it is also understandable that he persisted and soon became an outspoken advocate of Buchner's view; like Wroblewski and Pfeffer, he had already accepted the idea of an intracellular fermentation enzyme.The physiological chemists also fit the pattern in a special way. Physiological chemistry is generally regarded as the source of biochemistry; indeed, many early biochemists were trained in physiological chemistry, and imbibed there a progressive interest in enzymes and metabolism. It is not surprising, therefore, that on the whole Neumeister, Madfadyen, Wroblewski, and Loew accepted cell-free fermentation. But what is surprising, and significant, is the diversity of opinion in this group, from Abeles' living protoplasm to Wroblewski's organized array of active proteins. The feelings of the physiological chemists were mixed, and there was enough of the old protoplasm view in Macfadyen's and even Wroblewski's views to allow Buchner to see them as attacks on zymase. The ideas of physiological chemistry were also changing; the idea of protoplasm was already adjusting to the new interest in enzymes in the early 1890's. But in contrast to immunochemistry, the change in physiological chemistry was gradual, uneven, undramatic, and relatively invisible. For the new biochemistry, the tradition of physiological chemistry was the source of traditional conservatism as well as of new ideas of enzymes.In general, then, I claim that it was not experimental facts that determined attitudes toward zymase so much as previous commitments, experience, and expectations. Initially, at least, zymase was less a determinant of opinion than a touchstone of pre-existing opinion. Like a prism, it revealed the spectrum of existing attitudes toward vital phenomena.Also relevant here is the fact that the experimental evidence was entirely ambiguous; the interpretation of Buchner's experiments with antiseptics or dried yeast depended entirely on how far one was willing to stretch the scope of the terms “protoplasm” and “enzyme”. Likewise, how important one judged the instability of zymase to be, or the low level of in vitro activity, depended largely on one's point of view. There was no crucial experiment, no certain proof. Logically zymase could be regarded as protoplasm. A. Fischer did so in 1900;111 Macfadyen was still wavering in 1907;112 and Beijerinck was holding out as late as 1916.113 There were undoubtedly others. Besides the special case of Reynolds Green and the technologists, there are no recorded cases of conversion.But if there was no evidence to convert a dedicated protoplasmist, there was plenty to encourage a dedicated belief in the enzyme theory, and that, I believe, is precisely what happened. The arguments of Buchner et al in support of zymase had the greatest effect not on the protoplasmists but on those who were already predisposed toward the biochemical view. The zymase debate enabled the emerging group of biochemists to recognizethemselves as a group with a community of out-look and objectives; it brought the issue of protoplasm vs. enzyme into the open and gave it a specific and concrete issue on which to turn. The debate sharpened the biochemists' awareness that their point of view was becoming the new mainstream of biochemical thought.All this of course had an important secondary effect on those who opposed the new view, or who were not immediately concerned with it. After the zymase debate, it would have been almost impossible to ignore the new ideas; the dramatic and wide publicity the debate enjoyed would have made it difficult not to take sides. Buchner's successful defense of zymase itself became an important influence on opinion; the new movement had to be looked at with respect. But the primary effect of the debate, I assert, was on those who were already inclined to the new view. The outcome was not a mass conversion of individuals, nor the ejection of one idea by another. The sides probably did not change much; the real change was in the way each side regarded itself and its place in history. The zymase debate may perhaps best be regarded as a process of selection. Buchner's party became aware of itself as the new progressive point of view, while those holding the traditional view could no longer expound it publicly without appearing obstinate or old-fashioned. Thus the way was clear for the gradually wider establishment of the new ideas, especially among the new generation of biochemists. In this specific sense, the acceptance of zymase was a social phenomenon.This way of looking at the zymase debate also illuminates its coincidence with the emergence of biochemistry as a profession. The new professional trappings and organizations were the social manifestation of the new self-awareness gained from the zymase controversy. One of the most important effects on those disposed toward the new view was the awareness of an intellectual community and of the need to give that community social forms. The almost mythical importance of Buchner's “victory” over the old protoplasm theory that later became current is readily understandable. It was a useful ideology for a group anxious to assert the novelty of their approach, a novelty which they in fact felt quite keenly.But if the primary effect of the zymase controversy was on those predisposed to accept zymase, then obviously the success of zymase depended on the fact that change had already begun to occur. Indeed, one of the most striking, and again unexpected, results of this study is the extent to which the importance of enzymes was already recognized in the early 1890's. The new immunology clearly pointed the way. Macfadyen and Hans Buchner were looking for active proteins inside the cell in 1893. Reynolds Green, Wroblewski, and Pfeffer had all anticipated the discovery of a fermentation enzyme. Other discoveries in enzymology in the 1890's pointed the same way.114 Moreover, it is clear from this study that the old protoplams theory was adapting to the new discoveries concerning the importance of enzymes. The sidechains of the old protoplasm molecule were simply reinterpreted as enzymes, as in Wroblewski's theory, for example, or in Paul Ehrlich's extremely influential “sidechain theory” of antibody formation (1897). Despite the later views of Hopkins et al., the old protoplasm and the new enzyme theories were not irreconcilable; a continuity of development had already begun when zymase came so dramatically on the scene. Buchner himself observed that the difference between the two views had become largely verbal; in retrospect we might say, not verbal, but social and historical. The gap between the continuous change in ideas and the contemporary feeling of sharply discontnuous change is a measure of the elusive but real social and historical implications of the zymase debate, of the demise of an old establishment, and the emergence of a new.In retrospect, then, it is clear that a trend was already under way in various quarters when zymase appeared. But it was still a collection of isolated and dispersed events. The zymase controversy made the trend visible and gave it a dramatic unity. The debate influenced those who had already begun to change. It was so effective because things had begun to change and because it coincided with the direction of that trend. (shrink)